Search our team at AdventHealth Research Institute
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Edited Natural Killer cells as an immunotherapeutic approach for the treatment of pediatric cancers
This study is currently enrolling.Associated Conditions: Pediatric CancerResearch Area: Pediatrics ResearchResearch Location: Orlando, FloridaFreshly resected tumor tissue obtained from neuroblastoma patients will be used to establish in vitro organoid models and characterize the tumor landscape before and after in vitro allogeneic edited...
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NCT04089358
StepByStep: A Randomized Trial of a Mobile Health and Social Media Physical Activity Intervention among Adolescent and Young Adult Childhood Cancer Survivors
This study is currently enrolling.Associated Conditions: Pediatric CancerResearch Area: Cancer ResearchResearch Location: Orlando, FloridaThe overall goals of this study are: (1) To compare the effect of 2 different physical activity programs on physical activity levels in adolescents and young adults who received and completed...
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NCT02521493
CIRB/COG AAML1531 Risk-stratified Therapy for Acute Myeloid Leukemia in Down Syndrome
This study is currently enrolling.Associated Conditions: Pediatric CancerResearch Area: Cancer ResearchResearch Location: Orlando, FloridaThe overall goals of this study are to: To find out if subjects with standard risk DS AML can be treated with less treatment and still have successful outcomes. To find out if subjects with high risk...
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NCT03155620
NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice) Screening Protocol Study Title for Study Participants: Pediatric MATCH screening protocol
This study is currently enrolling.Associated Conditions: Multiple Tumor TypesResearch Area: Cancer ResearchResearch Location: Orlando, FloridaThe main purpose of this study is to learn how well tumors that have specific genetic changes (mutations) respond to drugs that target those changes. This combination of a tumor with a mutation and a...
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NCT03213678
NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice) - Phase 2 Subprotocol of LY3023414 in Patients with Solid Tumors
This study is not currently enrolling.Associated Conditions: Cancer, Multiple Tumor TypesResearch Area: Pediatrics ResearchResearch Location: Orlando, FloridaThis is a Phase 2 study of a drug called LY3023414. In a Phase 2 study, the goal is to find out what effects, good and/or bad, a drug has on your tumor or type of cancer.
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NCT03067181
A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients with Germ Cell Tumors
This study is not currently enrolling.Associated Conditions: Brain CancerResearch Area: Pediatrics ResearchResearch Location: Orlando, FloridaLow Risk Subjects (Age <50 Years): The overall goal is to see if monitoring subjects with low risk germ cell tumors after their tumor is removed is as effective as following surgery with chemotherapy...
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NCT03526250
NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice) - Phase 2 Subprotocol of Palbociclib in Patients with Tumors Harboring Activating Alterations in Cell Cycle Genes
This study is not currently enrolling.Associated Conditions: Cancer, Multiple Tumor TypesResearch Area: Pediatrics ResearchThe main goal of this study is to test any good and bad effects of the palbociclib on your tumor. A second goal of the study is to evaluate side effects that might be caused by palbociclib.
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NCT03233204
NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice) - Phase 2 Subprotocol of Olaparib in Patients with Tumors Harboring Defects in DNA Damage Repair Genes
This study is not currently enrolling.Associated Conditions: Cancer, All Tumor TypesResearch Area: Pediatrics ResearchThe main goal is to test any good and bad effects of the study drug olaparib on your tumor. A second goal of the study is to evaluate side effects that might be caused by olaparib and to learn more...
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NCT04284774
NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice) - Phase 2 subprotocol of Tipifarnib in Patients with Tumors Harboring HRAS Genomic Alterations
This study is not currently enrolling.Associated Conditions: Cancer, Multiple Tumor TypesResearch Area: Cancer ResearchResearch Location: Orlando, FloridaThis is a Phase 2 study of a study drug called tipifarnib. The main goal of the study is to find out what effect, good and/or bad effects the study drug tipifarnib may have on your tumor. A second...
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NCT03220035
NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice) - Phase 2 Subprotocol of Vemurafenib in Patients with Tumors Harboring BRAF V600 Mutations
This study is not currently enrolling.Associated Conditions: Cancer, All Tumor TypesResearch Area: Cancer ResearchResearch Location: Orlando, FloridaYou are being asked to participate in this study because you have relapsed or refractory tumor without a proven treatment strategy for cure. The main goal is to test any good and bad effects of the...
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NCT03698994
NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice) - Phase 2 Subprotocol of BVD-523FB (ulixertinib) in Patients with Tumors Harboring Activating MAPK Pathway Mutations
This study is not currently enrolling.Associated Conditions: Cancer, Multiple Tumor TypesResearch Area: Pediatrics ResearchYou are being asked to take part in this research study because your tumor results from the NCI-COG Pediatric MATCH screening protocol make you a candidate to receive the study drug called BVD-523FB...
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NCT03213704
NCI-COG Pediatric Match (Molecular Analysis for Therapy Choice) - Phase 2 Subprotocol of LOXO-101 (Larotrectinib) in Patients with Tumors Harboring Actionable NTRK Fusions
This study is not currently enrolling.Associated Conditions: Cancer, Companion StudyResearch Area: Cancer ResearchResearch Location: Orlando, FloridaThe overall goal of this study is to test any good and bad effects of the study drug LOXO-101 (larotrectinib) on your tumor.