Search our team at AdventHealth Research Institute
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NCT04195555
APEC1621K NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice) - Phase 2 Subprotocol of AG-120 (Ivosidenib) in Patients with Tumors Harboring IDH1 Mutations.
This study is not currently enrolling.Associated Conditions: Cancer, Multiple Tumor TypesResearch Area: Cancer ResearchResearch Location: Orlando, FloridaThe main goal is to find out what effect, good and/or bad effects AG-120 (ivosidenib) on your tumor. A second goal of the study is to evaluate side effects that might be caused by AG-120 (ivosidenib)...
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NCT05457556
A Feasibility and Randomized Phase 2/3 Study of the VEFGR2/MET Inhibitor Cabozantinib in Combination with Cytotoxic Chemotherapy for Newly Diagnosed Osteosarcoma
This study is not currently enrolling.Associated Conditions: Bone CancerResearch Area: Pediatrics ResearchThis study looks at how well cabozantinib in combination with MAP work when given to children and young adults with newly diagnosed OST disease. Cabozantinib is experimental because it has not been...
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NCT04166409
A Phase 3 Randomized Non-Inferiority Study of Carboplatin and Vincristine versus Selumetinib (NSC# 748727, IND# 77782) in Newly Diagnosed or Previously Untreated Low-Grade Glioma (LGG) not associated with BRAFV600E Mutations or Systemic Neurofibromatosis Type 1 (NF1)
This study is not currently enrolling.Associated Conditions: Brain CancerResearch Area: Pediatrics ResearchResearch Location: Orlando, FloridaThis study looks at how well a drug called selumetinib works when given to children and young adults with LGG. The study doctors want to see if selumetinib works as well as CV for getting rid of or...
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NCT03871257
A Phase 3 Randomized Study of Selumetinib (IND# 77782) versus Carboplatin/Vincristine in Newly Diagnosed or Previously Untreated Neurofibromatosis Type 1 (NF1) Associated Low-Grade Glioma (LGG)
This study is not currently enrolling.Associated Conditions: Brain CancerResearch Area: Pediatrics ResearchResearch Location: Orlando, FloridaThe overall goals of this study are to see if selumetinib works just as well as the standard treatment of carboplatin/vincristine (CV) for subjects with NF1-associated LGG, and to see if selumetinib...
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NCT05457556
A Multi-Center, Phase 3, Randomized Trial of Matched Unrelated Donor (MUD) versus HLA-Haploidentical Related (Haplo) Myeloablative Hematopoietic Cell Transplantation for Children, Adolescents, and Young Adults (AYA) with Acute Leukemia or Myelodysplastic Syndrome (MDS)
This study is currently enrolling.Associated Conditions: Cancer, Multiple Tumor TypesResearch Area: Pediatrics ResearchResearch Location: Orlando, FloridaYou are being asked to take part in this research study because you have been diagnosed with acute leukemia or myelodysplastic syndrome (MDS).