Search our team at AdventHealth Research Institute
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NCT06026410
KO-2806-001: Phase 1, First-in-Human, Multicenter, Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Antitumor Activity of KO-2806 When Administered as Monotherapy and in Combination Therapy in Adult Patients with Advanced Solid Tumors
This study is currently enrolling.Associated Conditions: Multiple Tumor TypesResearch Area: Cancer ResearchResearch Location: Celebration, FloridaThe purposes of this study are to:
• Determine the highest tolerable dose of KO-2806 given orally (by mouth) in combination with cabozantinib.
• Determine whether KO-2806 has an antitumor effect... -
NCT05301140
Vivistim Registry for Paired VNS Therapy (GRASP)
This study is currently enrolling.Research Area: Neuroscience ResearchResearch Location: Orlando, FloridaThe purpose of this particular registry is to collect information about patients who have had a stroke and still have upper-limb difficulties. This registry includes information before and after...
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NCT05654922
A Phase 3, Open-Label, Randomized, Standard of Care- Controlled, Parallel Arm Study to Demonstrate Efficacy and Safety of ARINA-1 in the Prevention of Bronchiolitis Obliterans Syndrome Progression in Participants with Bilateral Lung Transplant
This study is currently enrolling.Research Area: TransplantResearch Location: Orlando, FloridaThe purpose of this research study is to see if the investigational drug, ARINA-1 when used with the investigational PARI eFlow nebulizer system, can stabilize or improve the lung function of...
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EX-BOOST: Exercise to boost response to checkpoint blockade immunotherapy
This study is currently enrolling.Research Area: Translational ResearchResearch Location: Orlando, FloridaStudy Purpose: To obtain a better understanding on how exercise can improve outcomes for patients with skin cancers.
To be enrolled in this study, you must meet certain requirements. You may be...
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NCT05563220
STML-ELA-022 A Phase 1b/2, Open-Label Umbrella Study To Evaluate Safety And Efficacy Of Elacestrant In Various Combination In Patients With Metastatic Breast Cancer (ELEVATE)
This study is currently enrolling.Associated Conditions: Breast CancerResearch Area: Cancer ResearchResearch Location: Altamonte, FloridaThis research study is being done to find out if elacestrant is safe and tolerable when given in combination with one of the following study drugs, approved in the treatment of advanced breast cancer...
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NCT05677100
DiuRetics Alone vs. AortIx ENdovascular Device for Acute Heart Failure (DRAIN HF)
This study is currently enrolling.Research Area: Heart, Lung and Vascular ResearchResearch Location: Tampa, FloridaThe purpose of this research is to evaluate the investigational Aortix System. The Aortix System is not approved by the FDA. The system has been designed for use in patients hospitalized with heart...
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NCT05865535
AV-380-22-102: A Phase 1 Dose Escalation Study of AV-380 in Combination with Standard of Care Chemotherapy in Metastatic Cancer Patients with Cachexia and Elevated GDF-15 Levels
This study is currently enrolling.Research Area: Cancer ResearchResearch Location: Orlando, FloridaThe study involves research. The purpose of the study is to see if a single dose and multiple doses of the study drug, AV 380, are safe and tolerated in cancer participants. This study will also help...
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NCT04956640
LOXO-RAS-20001: A Phase 1a/1b Study of LY3537982 in Patients with KRAS G12C-Mutant Advanced Solid Tumors
This study is currently enrolling.Research Area: Cancer ResearchResearch Location: Orlando, FloridaThe main purpose of this research study (during both monotherapy and combination therapy evaluation) includes the following: To determine whether LY3537982 is safe; To identify which dose level of...
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NCT04427384
A Multicenter Observational Study of GammaTile™ Surgically Targeted Radiation Therapy (STaRT) in Intracranial Brain Neoplasms
This study is currently enrolling.Associated Conditions: Brain CancerResearch Area: Cancer ResearchResearch Location: Orlando, FloridaThe purpose of this research is to evaluate real-world clinical outcomes and patient-reported
outcomes that measure the effectiveness and safety of GammaTiles, which is the type of
radiation therapy... -
NCT05346835
68284528MMY4006 EAP: Intermediate-Size Population Expanded Access Program (EAP) for Ciltacabtagene Autoleucel (Cilta-cel) Out-of-Specification (OOS) in Patients With Multiple Myeloma
This study is currently enrolling.Associated Conditions: Multiple MyelomaResearch Area: Cancer ResearchResearch Location: Orlando, Florida -
NCT05948865
CPO301-US-101: A Phase 1, Multicenter, Single Agent Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Evidence of Antitumor Activity of CPO301, an EGFR-Targeting Antibody-Drug Conjugate, in Adult Patients with Advanced or Metastatic Solid Tumors
This study is currently enrolling.Associated Conditions: Multiple MyelomaResearch Area: Cancer ResearchResearch Location: Orlando, FloridaThe purpose of the study, called CPO301-US-101, is to see if CPO301 (also known as SYS6010) is safe and effective in treating your type of cancer when administered as an intravenous (administered into...
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NCT05685303
ALLAY-HF: Safety and Efficacy of the Alleviant System for No-Implant Interatrial Shunt Creation in Patients with Chronic Heart Failure
This study is currently enrolling.Research Area: Heart, Lung and Vascular ResearchResearch Location: Orlando, FloridaTo evaluate the safety and efficacy of the Alleviant ALV1 System in
patients with chronic heart failure (HF) and preserved ejection fraction
(HFpEF) or mildly reduced ejection fraction (HFmrEF), who...