Search our team at AdventHealth Research Institute
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NCT04529772
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Acalabrutinib in Combination with Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R CHOP) in Subjects ≤70 Years with Previously Untreated Non-Germinal Center Diffuse Large B Cell Lymphoma
This study is not currently enrolling.Associated Conditions: LeukemiaResearch Area: Cancer ResearchResearch Location: Orlando, FloridaThis study is being done to understand whether patients with a type of DLBCL known as non-germinal center diffuse large B-cell lymphoma (non-GCB DLBCL) will benefit from the addition of acalabrutinib...
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NCT03000439
You are being asked to take part in this research study because you have Systemic Juvenile Idiopathic Arthritis (sJIA) which may cause joint swelling and pain, fever, or other symptoms affecting the whole body (such as rash, swelling of your lymph nodes, a large liver or spleen, or inflammation of the lining around your lungs or heart). The purpose of this research study is to compare the effectiveness of the study drug, tofacitinib, to placebo for treatment of signs and symptoms of sJIA.
This study is not currently enrolling.Associated Conditions: Immunology/RheumatologistResearch Area: Cancer ResearchResearch Location: Orlando, FloridaYou are being asked to take part in this research study because you have Systemic Juvenile Idiopathic Arthritis (sJIA) which may cause joint swelling and pain, fever, or other symptoms affecting the...
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NCT04537377
A Phase I/II, Multicenter, Non-randomized, Open Label, Adaptive Design, 5-year Follow up, Single Dose-escalation Study of VTX-801 in Adult Patients with Wilson’s Disease.
This study is not currently enrolling.Associated Conditions: Wilsons DiseaseResearch Area: Cancer ResearchResearch Location: Orlando, FloridaThis Clinical Trial is being conducted to assess the effects of an experimental drug (study drug) called VTX-801 intended to treat Wilson’s Disease (WD). The purpose of this clinical study is to...
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NCT04137900
A First-in-Human, Multicenter, Open-Label, Phase 1 Dose-Escalation and Cohort Expansion Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TAB004 as Monotherapy and in Combination with Toripalimab in Subjects with Advanced Solid Malignancies including Lymphoma
This study is not currently enrolling.Associated Conditions: LymphomaResearch Area: Cancer ResearchThe purpose of this study is to determine the side effects of TAB004 (investigational drug) when given alone or in combination with toripalimab (another investigational drug), to determine a...
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NCT03517332
Association of ctDNA and circulating tumor cells after neoadjuvant chemotherapy with disease recurrence in patients with advanced stage epithelial ovarian cancer, fallopian tube cancer, or primary peritoneal cancer.
This study is not currently enrolling.Associated Conditions: Ovarian, Fallopian, or Primary Peritoneum CancerResearch Area: Cancer ResearchTo compare the levels of ctDNA and CTCs using the SIGNATERA™ test in the peripheral blood of patients during neoadjuvant chemotherapy and after IDS for advanced stage epithelial ovarian carcinoma...
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Optune Lua for the treatment of adult patients with unresectable, locally advanced or metastatic, malignant pleural mesothelioma (MPM) to be used concurrently with pemetrexed and platinum-based chemotherapy
This study is not currently enrolling.Associated Conditions: Malignant Pleural MesotheliomaResearch Area: Cancer ResearchOptune Lua is indicated for the treatment of adult patients with unresectable, locally advanced or metastatic, malignant pleural mesothelioma (“MPM”) to be used concurrently with pemetrexed and...
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NCT05107856
A Phase 1, Open-Label, Multicenter, Dose Escalation Study of PRT1419 Injection in Patients with Relapsed/Refractory Hematologic Malignancies
This study is not currently enrolling.Associated Conditions: LeukemiaResearch Area: Cancer ResearchThe purpose of this research study is to test the safety of PRT1419 at different dose levels to find out what effects, good and/or bad, PRT1419 has on you and your type of cancer. The information...
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NCT04669899
Phase 1 First-in-Human Study of Leukocyte Immunoglobulin-Like Receptor B2 (LILRB2) Inhibitor Monoclonal Antibody (mAb) JTX8064, as Monotherapy and in Combination with a Programmed Cell Death Receptor-1 (PD-1) Inhibitor, in Adult Subjects with Advanced Refractory Solid Tumor Malignancies
This study is not currently enrolling.Associated Conditions: Multiple MyelomaResearch Area: Cancer ResearchA medical research study for participants who have been diagnosed with a solid tumor (i.e. cancer) and currently, the tumor is unresponsive to approved treatments, approved treatments are worsening...
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NCT04998747
A Phase 1b Open-label Study Evaluating the Safety and Pharmacokinetics of Subcutaneous AMG 701 for the Treatment of Relapsed or Refractory Multiple Myeloma (ProxiMMity-1)
This study is not currently enrolling.Associated Conditions: Multiple MyelomaResearch Area: Cancer ResearchParticipants who have have relapsed (returning) and refractory (stopped responding to treatment) multiple myeloma (RRMM) will be invited to take part in this study. This study is being done to learn...
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NCT04935359
A randomized, three-arm, double-blind, placebo-controlled, phase III study, comparing NIS793 with or without spartalizumab in combination with gemcitabine and nab-paclitaxel versus matching placebos combined with gemcitabine and nab-paclitaxel for first line treatment of metastatic pancreatic ductal adenocarcinoma (mPDAC)
This study is not currently enrolling.Associated Conditions: Pancreatic CancerResearch Area: Cancer ResearchResearch Location: Orlando, FloridaThe purpose of this study is to evaluate the efficacy and safety of NIS793 in combination with gemcitabine/nab-paclitaxel versus gemcitabine/nab-paclitaxel and placebo in first-line mPDAC. This study...
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Phase II Trial of Trilaciclib added to Chemotherapy plus Pembrolizumab in the First-line Treatment of patients with Advanced Non-Small Cell Lung Cancer.
This study is not currently enrolling.Associated Conditions: Lung CancerResearch Area: Cancer Research -
Prospective Registry for Colorectal Cancer: International Watch and Wait Database
This study is not currently enrolling.Associated Conditions: Colorectal CancerResearch Area: Cancer ResearchThis research is being done as part of a larger international database for 'Watch and Wait' rectal cancer patients. Currently, the 'Watch and Wait' treatment shows promising results worldwide, however...