Search our team at AdventHealth Research Institute
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NCT03919071
A Phase 2 Study of Dabrafenib (NSC# 763760) with Trametinib (NSC# 763093) after Local Irradiation in Newly Diagnosed BRAFV600-Mutant High-Grade Glioma (HGG) (IND# 145355)
This study is currently enrolling.Associated Conditions: Brain CancerResearch Area: Cancer ResearchThe study doctors want to see if using dabrafenib and trametinib after radiation treatment will be better than treatments used in the past in helping to get rid of or shrink HGGs. Dabrafenib works by...
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NCT03959085
A Phase 3 Randomized Trial of INotuzumab Ozogamicin (IND#: 133494, NSC#: 772518) for Newly Diagnosed High-Risk B-ALL; Risk-Adapted Post-Induction Therapy for High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and Disseminated B-LLy
This study is currently enrolling.Associated Conditions: LeukemiaResearch Area: Cancer ResearchDisseminated B-Cell Lymphoblastic Lymphoma (B-LLy): The overall goal of this study is to determine the outcomes of subjects with disseminated B-LLy receiving High Risk B-cell Acute Lymphoblastic...
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NCT02981628
A Phase 2 Study of INotuzumab Ozogamicin (NSC# 772518, IND #133494) in Children and Young Adults with Relapsed or Refractory CD22+ B-Acute Lymphoblastic Leukemia (B-ALL)
This study is currently enrolling.Associated Conditions: LeukemiaResearch Area: Cancer ResearchResearch Location: Orlando, FloridaThe overall goal of this study is to find out what effect, good and/or bad, the drug inotuzumab ozogamicin has on children and young adults with relapsed or refractory B-ALL.
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NCT03126916
A Phase 3 Study of 131I-Metaiodobenzylguanidine (131I-MIBG) or Crizotinib Added to Intensive Therapy for Children with Newly Diagnosed High-Risk Neuroblastoma
This study is currently enrolling.Associated Conditions: Brain CancerResearch Area: Cancer ResearchThe overall goals of this study are to: Compare the effects, good and/or bad, of the experimental drug 131I-MIBG added to current COG recommended therapy to the effects of current COG recommended...
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NCT00736749
Umbrella Long-Term Follow-Up Protocol
This study is currently enrolling.Associated Conditions: Companion StudyResearch Area: Cancer ResearchResearch Location: Orlando, FloridaThe overall goal of this study is to keep in contact with participants of COG clinical trials, so that up-to-date information will be available about these participants as they get older. This...
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NCT00898365
Renal Tumors Classification, Biology, and Banking Study
This study is currently enrolling.Associated Conditions: Kidney CancerResearch Area: Cancer ResearchResearch Location: Orlando, FloridaOver the past years, many studies have been done for children with kidney tumors. Each study done has increased what we know about these tumors and has helped doctors plan treatment for subjects with...
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NCT02521493
CIRB/COG AAML1531 Risk-stratified Therapy for Acute Myeloid Leukemia in Down Syndrome
This study is currently enrolling.Associated Conditions: Pediatric CancerResearch Area: Cancer ResearchResearch Location: Orlando, FloridaThe overall goals of this study are to: To find out if subjects with standard risk DS AML can be treated with less treatment and still have successful outcomes. To find out if subjects with high risk...
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NCT02402244
The Project: EveryChild Protocol: A Registry, Eligibility Screening, Biology and Outcome Study
This study is currently enrolling.Associated Conditions: Multiple Tumor TypesResearch Area: Cancer ResearchResearch Location: Orlando, FloridaWe are doing this study to find better ways to diagnose, treat and prevent cancers in children, adolescents and young adults. To do this, we need to learn more about cancers that happen to children...
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NCT03155620
NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice) Screening Protocol Study Title for Study Participants: Pediatric MATCH screening protocol
This study is currently enrolling.Associated Conditions: Multiple Tumor TypesResearch Area: Cancer ResearchResearch Location: Orlando, FloridaThe main purpose of this study is to learn how well tumors that have specific genetic changes (mutations) respond to drugs that target those changes. This combination of a tumor with a mutation and a...
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NCT01515787
A Phase II/III of Neoadjuvant FOLFOX with Selective Use of Combined Modality Chemoradiation versus Preoperative Combined Modality Chemoradiation for Locally Advanced Rectal Cancer Patients Undergoing Low Anterior Resection with Total Mesorectal Excision (PROSPECT)
This study is currently enrolling.Associated Conditions: Colorectal CancerResearch Area: Cancer ResearchResearch Location: Orlando, Florida[$] [Abbreviated - Closed] The purpose of this study is to compare the effects, both good and bad, of the standard treatment of chemotherapy and radiation to chemotherapy using a combination regimen...
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NCT06172478
A Phase 2, Multicenter, Multicohort, Open-Label, Proof of Concept Study of Patritumab Deruxtecan (HER3-DXd; U3-1402) in Subjects With Locally Advanced or Metastatic Solid Tumors
This study is not currently enrolling.Research Area: Cancer ResearchThe purpose of this study is to learn more about an investigational drug called patritumab deruxtecan (also known as HER3-DXd or U3-1402), also referred to as “study drug” or “study treatment”...
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NCT06065748
A Phase III Randomized, Open-Label Study Evaluating Efficacy and Safety of Giredestrant Compared With Fulvestrant, Both Combined With a CDK4/6 Inhibitor, in Patients With Estrogen Receptor-Positive, HER2-Negative Advanced Breast Cancer With Resistance to Prior Adjuvant Endocrine Therapy (pionERA Breast Cancer)
This study is not currently enrolling.Research Area: Cancer ResearchResearch Location: Altamonte, FloridaThe purpose of this study is to compare the effects, good or bad, of two hormonal treatments, giredestrant and fulvestrant, both given in combination with your study doctor’s choice of a class of...