Search our team at AdventHealth Research Institute
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Isolation of Tumor Cells, Cancer Stem Cells and Human Neuronal Stem Cells from Human Brain Tumor Tissue for Analysis of Cancer Stem Cell Markers’ Expression in Cellular Differentiation and Self-renewal for Studying the Effectiveness of Cancer Therapy with Subsequent Identification of Exosomal Biomarkers for Early Diagnostic Purposes
This study is currently enrolling.Associated Conditions: Brain Diseases/CAResearch Area: Neuroscience ResearchResearch Location: Orlando, FloridaThe purpose of this clinical trial is to collect and study brain tumor samples to help understand why the tumor grows back and to seek new ways to treat it.
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NCT04427384
A Multicenter Observational Study of GammaTile™ Surgically Targeted Radiation Therapy (STaRT) in Intracranial Brain Neoplasms
This study is currently enrolling.Associated Conditions: Brain CancerResearch Area: Cancer ResearchResearch Location: Orlando, FloridaThe purpose of this research is to evaluate real-world clinical outcomes and patient-reported
outcomes that measure the effectiveness and safety of GammaTiles, which is the type of
radiation therapy... -
NCT04365374
GTM-102: A Phase 3 Randomized Controlled Trial of Post-Surgical Stereotactic Radiotherapy (SRT) versus Surgically Targeted Radiation Therapy (STaRT) with Gamma Tile for Treatment of Newly Diagnosed Metastatic Brain Tumors
This study is currently enrolling.Associated Conditions: Brain CancerResearch Area: Cancer ResearchResearch Location: Orlando, FloridaThe purpose of this research study is to compare surgical tumor removal followed by stereotactic radiotherapy (SRT) to surgical tumor removal followed by radiation therapy delivered by surgically...
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NCT05685004
Randomized controlled Phase 2b clinical trial to evaluate the safety and efficacy of TVI-Brain-1 combined with conformal radiotherapy and temozolomide compared to standard therapy as a treatment for newly diagnosed O6-methylguanine methyltransferase negative (MGMT unmethylated) grade 4 astrocytoma (glioblastoma multiforme; glioblastoma; GBM).
This study is not currently enrolling.Associated Conditions: Brain CancerResearch Area: Cancer ResearchThis clinical trial is being performed because there is a need for safer and more effective treatments for glioblastomas. The purpose of this specific clinical study is to determine how safe and...
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NCT03919071
A Phase 2 Study of Dabrafenib (NSC# 763760) with Trametinib (NSC# 763093) after Local Irradiation in Newly Diagnosed BRAFV600-Mutant High-Grade Glioma (HGG) (IND# 145355)
This study is currently enrolling.Associated Conditions: Brain CancerResearch Area: Cancer ResearchThe study doctors want to see if using dabrafenib and trametinib after radiation treatment will be better than treatments used in the past in helping to get rid of or shrink HGGs. Dabrafenib works by...
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NCT03126916
A Phase 3 Study of 131I-Metaiodobenzylguanidine (131I-MIBG) or Crizotinib Added to Intensive Therapy for Children with Newly Diagnosed High-Risk Neuroblastoma
This study is currently enrolling.Associated Conditions: Brain CancerResearch Area: Cancer ResearchThe overall goals of this study are to: Compare the effects, good and/or bad, of the experimental drug 131I-MIBG added to current COG recommended therapy to the effects of current COG recommended...
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NCT03856099
A Multicenter, Open-Label, Phase Ⅱ Clinical Trial to Evaluate the Safety and Efficacy of TTAC-0001, a Fully Human Monoclonal Antibody in Patients with Recurrent Glioblastoma Progressed on Bevacizumab Including Therapy
This study is not currently enrolling.Associated Conditions: Brain CancerResearch Area: Cancer ResearchThe aim of this study is to assess the safety and effectiveness of the study drug, TTAC-0001 to patients with recurrent glioblastoma which has progressed on bevacizumab treatment. Another aim is to...
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NCT04166409
A Phase 3 Randomized Non-Inferiority Study of Carboplatin and Vincristine versus Selumetinib (NSC# 748727, IND# 77782) in Newly Diagnosed or Previously Untreated Low-Grade Glioma (LGG) not associated with BRAFV600E Mutations or Systemic Neurofibromatosis Type 1 (NF1)
This study is not currently enrolling.Associated Conditions: Brain CancerResearch Area: Pediatrics ResearchResearch Location: Orlando, FloridaThis study looks at how well a drug called selumetinib works when given to children and young adults with LGG. The study doctors want to see if selumetinib works as well as CV for getting rid of or...
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NCT03871257
A Phase 3 Randomized Study of Selumetinib (IND# 77782) versus Carboplatin/Vincristine in Newly Diagnosed or Previously Untreated Neurofibromatosis Type 1 (NF1) Associated Low-Grade Glioma (LGG)
This study is not currently enrolling.Associated Conditions: Brain CancerResearch Area: Pediatrics ResearchResearch Location: Orlando, FloridaThe overall goals of this study are to see if selumetinib works just as well as the standard treatment of carboplatin/vincristine (CV) for subjects with NF1-associated LGG, and to see if selumetinib...
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NCT03067181
A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients with Germ Cell Tumors
This study is not currently enrolling.Associated Conditions: Brain CancerResearch Area: Pediatrics ResearchResearch Location: Orlando, FloridaLow Risk Subjects (Age <50 Years): The overall goal is to see if monitoring subjects with low risk germ cell tumors after their tumor is removed is as effective as following surgery with chemotherapy...