Search our team at AdventHealth Research Institute
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LAMBDA study: Longitudinal Assessment of Multidomain Brain data for early Detection of Alzheimer’s disease LAMBDA
This study is currently enrolling.Associated Conditions: AlzheimersResearch Area: Neuroscience ResearchResearch Location: Orlando, FloridaStudy Purpose: This study will be examining changes in memory and mental function and several biological variables in aging. Examining the biology underlying memory changes could influence our...
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NCT05919511
MA-GVHD-401: A Prospective, Observational Cohort Study of Participants at Risk for Chronic Graft-Versus-Host Disease in the United States (THRIVE)
This study is currently enrolling.Research Area: Cancer ResearchResearch Location: Orlando, FloridaDescribe the clinical course and burden of cGVHD after alloSCT. Describe personal and healthcare resource utilization associated with the management of
cGVHD. Describe practice patterns and therapy... -
NCT06040099
D933GC00002: A Phase II Single-Arm Study of Durvalumab and Bevacizumab Following Transarterial Radioembolization Using Yttrium-90 Glass Microspheres (TheraSphere™) in Unresectable Hepatocellular Carcinoma
This study is currently enrolling.Research Area: Cancer ResearchResearch Location: Orlando, FloridaAstraZeneca is doing this study to learn more about durvalumab and bevacizumab given together after the TARE Y90 procedure in participants with HCC, and also to better understand HCC and associated...
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FABULINUS: A 52-week randomized, double-blind, placebo controlled, multi-center Phase 2b study with a 52-week blinded extension assessing safety and efficacy of frexalimab, a CD40L-antagonist monoclonal antibody, for preservation of pancreatic beta-cell function in adults and adolescents with newly diagnosed type 1 diabetes on insulin therapy.
This study is currently enrolling.Research Area: Translational ResearchResearch Location: Orlando, FloridaStudy Purpose: The study is aimed to evaluate an investigational drug, frexalimab, for preservation of pancreatic beta cell function in adults and adolescents that have been newly diagnosed with Type...
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NCT05128825
A Phase 2 Open-Label, Multicenter Study To Evaluate Efficacy And Safety Of Zn-C3 In Subjects With High-Grade Serous Ovarian, Fallopian Tube, Or Primary Peritoneal Cancer
This study is currently enrolling.Research Area: Cancer ResearchResearch Location: Orlando, FloridaThe purpose of this Study includes the following: To test the safety of the Study drug and how you will feel while taking the Study drug. To find out what effects, good and/or bad, it has on you and...
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NCT06064877
AV-299-23-301: A Phase 3 Study of Ficlatuzumab in Combination with Cetuximab in Subjects with Recurrent or Metastatic (R/M) HPV-Negative Head and Neck Squamous Cell Carcinoma
This study is currently enrolling.Associated Conditions: ThoracicResearch Area: Cancer ResearchResearch Location: Orlando, FloridaThe main purpose of this study is to investigate the safety, effectiveness, and tolerability (whether side effects can be handled by a participant) of ficlatuzumab at two different doses when given...
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NCT06143891
A randomized, double-blind, multicenter, Phase 3 study to evaluate efficacy and safety of belumosudil in combination with corticosteroids versus placebo in combination with corticosteroids in participants at least 12 years of age with newly diagnosed chronic graft versus host disease (cGVHD)) (ROCKnrol-1)
This study is currently enrolling.Research Area: Cancer ResearchResearch Location: Orlando, FloridaDemonstrate the superiority of belumosudil in combination with prednisone vs placebo in combination with prednisone in event free survival.
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NCT06305767
A Phase 2, Randomized, Double-blind Study of Adjuvant V940 (mRNA-4157) + Pembrolizumab (MK-3475) vs. Placebo + Pembrolizumab for High-Risk Muscle-Invasive Urothelial Carcinoma (MIUC) Post-Radical Resection
This study is currently enrolling.Associated Conditions: Urothelial CancerResearch Area: Cancer ResearchResearch Location: Orlando, FloridaTo compare V940 plus pembrolizumab to
placebo plus pembrolizumab with respect to DFS. Hypothesis (H1): V940 plus pembrolizumab is superior to placebo plus pembrolizumab with respect to DFS as assessed... -
NCT03142152
Assessment of the Carillon Mitral Contour System® in Treating Heart Failure with Functional Mitral Regurgitation
This study is currently enrolling.Research Area: TransplantResearch Location: Orlando, FloridaThe purpose of this clinical study is to evaluate the safety and effectiveness of the Carillon Mitral Contour System in people who have mitral regurgitation resulting from heart failure.
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NCT05478304
Left Atrial Appendage Exclusion for Prophylactic Stroke Reduction Trial (LeAAPS)
This study is currently enrolling.Research Area: Heart, Lung and Vascular ResearchResearch Location: Orlando, FloridaThe purpose of the trial is to test if closing off the LAA with a surgical device known as the AtriClip reduces stroke occurrence in patients like yourself, who do not have AF but who have one or more...
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NCT05520099
Observational basket trial to predict response to immune checkpoint inhibitors across solid tumors using a live tumor diagnostic platform (CYBRID-02)
This study is currently enrolling.Research Area: Cancer ResearchResearch Location: Orlando, Florida -
NCT05301140
Vivistim Registry for Paired VNS Therapy (GRASP)
This study is currently enrolling.Research Area: Neuroscience ResearchResearch Location: Orlando, FloridaThe purpose of this particular registry is to collect information about patients who have had a stroke and still have upper-limb difficulties. This registry includes information before and after...