Search our team at AdventHealth Research Institute
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COMET: ImpaCt Of shiftwork on METabolic Flexibility and Skeletal Muscle Clocks.
This study is currently enrolling.Research Area: Translational ResearchResearch Location: Orlando, FloridaStudy Purpose: To determine how working a nighttime shift impacts your metabolism.
To be enrolled in this study, you must meet certain requirements. You may be eligible to participate if you meet the...
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NCT05610163
THE JANUS RECTAL CANCER TRIAL: A RANDOMIZED PHASE II TRIAL TESTING THE EFFICACY OF TRIPLET VERSUS DOUBLET CHEMOTHERAPY TO ACHIEVE CLINICAL COMPLETE RESPONSE IN PATIENTS WITH LOCALLY ADVANCED RECTAL CANCER
This study is currently enrolling.Associated Conditions: Colorectal CancerResearch Area: Cancer ResearchResearch Location: Orlando, FloridaTo evaluate and compare the cCR rates in patients with locally advanced rectal cancer treated with neoadjuvant LCRT followed by neoadjuvant mFOLFIRINOX versus neoadjuvant LCRT followed by neoadjuvant...
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NCT04365374
GTM-102: A Phase 3 Randomized Controlled Trial of Post-Surgical Stereotactic Radiotherapy (SRT) versus Surgically Targeted Radiation Therapy (STaRT) with Gamma Tile for Treatment of Newly Diagnosed Metastatic Brain Tumors
This study is currently enrolling.Associated Conditions: Brain CancerResearch Area: Cancer ResearchResearch Location: Orlando, FloridaThe purpose of this research study is to compare surgical tumor removal followed by stereotactic radiotherapy (SRT) to surgical tumor removal followed by radiation therapy delivered by surgically...
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NCT05778188
A Phase 2, Two-Stage, Randomized, Double-Blind, Placebo-Controlled, Multiple-Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of RLS-0071 in Newborns with Moderate or Severe Hypoxic Ischemic Encephalopathy Undergoing Therapeutic Hypothermia with Long-Term Follow-Up (STAR)
This study is currently enrolling.Research Area: Pediatrics ResearchResearch Location: Orlando, FloridaThis study is being conducted to learn whether the investigational medication, called RLS-0071, may help babies, such as your own, who are affected by hypoxic-ischemic encephalopathy (HIE). HIE is a...
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NCT05754333
ASP5354: A Phase 3, Multicenter, Prospective, Randomized, Open-label Study for Intraoperative Ureter(s) Visualization When Using ASP5354 with Near-infrared Fluorescence (NIR-F) Imaging in Participants Undergoing Minimally Invasive and Open Abdominopelvic Surgeries.
This study is currently enrolling.Research Area: Digestive Health and SurgeryResearch Location: Orlando, FloridaStudy Purpose: The biological father of your child is/was participating in a research study of an Investigational or experimental medicine that has not received approval from governmental regulatory...
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B044157 A Phase II, Randomized, Multicenter, Open-Label, Controlled Study Of R07247669 Alone Or In Combination With Tiragolumab Versus Atezolizumab In Patients With Previously Untreated Locally Advanced Or Metastatic Urothelial Bladder Cancer Who Are Ineligible For Platinum-Containing Chemotherapy
This study is currently enrolling.Associated Conditions: Urothelial CancerResearch Area: Cancer ResearchResearch Location: Orlando, Florida -
NCT05506943
A Phase 2/3 Randomized, Controlled Study of CTX-009 in Combination with Paclitaxel versus Paclitaxel Alone in Adult Patients with Unresectable Advanced, Metastatic or Recurrent Biliary Tract Cancers who have received One Prior Systemic Chemotherapy Regimen
This study is currently enrolling.Associated Conditions: Biliary Tract CancerResearch Area: Cancer ResearchResearch Location: Orlando, Florida -
Comparative effectiveness of Juntos Después del Cáncer (JDC) among Breast Cancer Survivors and their Intimate Partners
This study is currently enrolling.Research Area: Cancer ResearchResearch Location: Orlando, Florida -
NCT05508906
A Phase 1b Open-Label Multicenter Study of OP-1250 in Combination with the CDK4/6 Inhibitor Ribociclib or with the PI3K Inhibitor Alpelisib in Adult Subjects with Advanced and/or Metastatic HR Positive, HER2 Negative Breast Cancer
This study is currently enrolling.Associated Conditions: Breast CancerResearch Area: Cancer ResearchResearch Location: Orlando, FloridaParticipants will be invited to take part in this clinical research study if they have been treated for hormone receptor (HR)-positive and human epidermal growth factor receptor 2 negative (HER2)...
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NCT05261399
We are doing this research study to learn more about an investigational drug called savolitinib in combination with osimertinib for the treatment of non-small cell lung cancer (NSCLC). Investigational means that the drug is not approved by any health authority, except for use in research studies like this. Osimertinib is approved by health authorities for treatment of NSCLC. Osimertinib is known to work well initially, but resistance often occurs after several months of treatment.
This study is currently enrolling.Associated Conditions: Lung CancerResearch Area: Cancer ResearchResearch Location: Orlando, FloridaWe are doing this research study to learn more about an investigational drug called savolitinib in combination with osimertinib for the treatment of non-small cell lung cancer (NSCLC). Investigational...
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NCT04836390
A Phase II Pilot Study of Donor-Derived Ex-VivoExpanded Natural Killer Cell Infusions in Childrenand Young Adults with High-Risk Acute Myeloid Leukemia Receiving Myeloablative HLA Haploidentical Hematopoietic Cell Transplant: A Multicenter Pediatric Transplantation and Cellular Therapy Consortium (PTCTC) Study (EXCEL Trial) PTCTC CT2001.
This study is currently enrolling.Associated Conditions: LeukemiaResearch Area: Cancer ResearchResearch Location: Orlando, FloridaParticipants will be invited to join this study if they have a blood disease called acute myeloid leukemia (AML) and it has been decided that they need a transplant as part of their treatment plan....
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NCT02582697
Phase 3 Accelerated BEP Trial: A randomized phase 3 trial of accelerated versus standard BEP chemotherapy for patients with intermediate and poor-risk metastatic germ cell tumors.
This study is currently enrolling.Research Area: Pediatrics ResearchResearch Location: Orlando, Florida