Search our team at AdventHealth Research Institute
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NCT04798261
STRIKE-PE: A Prospective, Multicenter Study of the Indigo Aspiration System Seeking to Evaluate the Long-Term Safety and Outcomes of Treating Pulmonary Embolism
This study is currently enrolling.Associated Conditions: Pulmonary EmbolismResearch Area: Heart, Lung and Vascular ResearchResearch Location: Orlando, FloridaYour study doctor has determined you have or have had a pulmonary embolism (PE). A PE is a blood clot in an artery or arteries in your lung. A clot can be life threatening if immediate action is not...
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NCT04807868
AVAIL: AdventHealth Research Institute Non-Alcoholic Fatty Liver Disease Biobank and Registry
This study is currently enrolling.Associated Conditions: Liver-NAFL, NASHResearch Area: Translational ResearchResearch Location: Orlando, FloridaNon-alcoholic fatty liver disease (NAFLD) is a common liver disease that leads to many health complications. Many people have this disease and do not know it. There are no medications available to...
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NCT04793958
A Randomized Phase 3 Study of MRTX849 in Combination with Cetuximab Versus Chemotherapy in Patients with Advanced Colorectal Cancer with KRAS G12C Mutation with Disease Progression On or After Standard First-Line Therapy
This study is currently enrolling.Associated Conditions: Colorectal CancerResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThis is a study involving an investigational (experimental) drug called MRTX849, being developed by Mirati Therapeutics, Inc., which is the company that provides MRTX849 study drug and is funding and...
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NCT04221815
IMPROVE: MedStar Cardiovascular Research Network/IMPact on Revascularization Outcomes of intraVascular ultrasound guided treatment of complex lesions and Economic impact
This study is currently enrolling.Associated Conditions: AtherosclerosisResearch Area: Heart, Lung and Vascular ResearchResearch Location: Orlando, FloridaThe study will assess whether the use of IVUS improves subjects’ clinical outcomes at 1 year following this PCI procedure. These subjects will be compared to subjects who did not undergo such IVUS...
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NCT04291612
Sentinel Lymph Node Endometrial Cancer Trial: A Prospective Multicenter International Single-Arm Observational Trial (SELECT)
This study is currently enrolling.Associated Conditions: Endometrial CancerResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaWe are doing this study to find out how often your type of cancer comes back (recurs) after the standard treatment. We also want to see how often the standard treatment results in a buildup of fluid...
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Pilot Feasibility Study of the Interplay between the Host Gut Microbiome and Efficacy of Treatment for Epithelial Ovarian Cancer Patients Receiving IMmunotherapy
This study is currently enrolling.Associated Conditions: Ovarian, Fallopian, or Primary Peritoneum CancerResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThis research is being done to see if your gut microbiome (microorganisms that live in the gut) could help as a biomarker of clinical response to immunotherapy.
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NCT04393285
A Phase II Study of Abemaciclib in Combination with Letrozole in Advanced, Recurrent or Metastatic Endometrioid Endometrial Cancer
This study is currently enrolling.Associated Conditions: Endometrial CancerResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThe purpose of this study is to find out if the combination of the drugs abemaciclib and letrozole is better or worse than usual approach for your type of cancer. The usual approach is defined as care...
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NCT04166409
A Phase 3 Randomized Non-Inferiority Study of Carboplatin and Vincristine versus Selumetinib (NSC# 748727, IND# 77782) in Newly Diagnosed or Previously Untreated Low-Grade Glioma (LGG) not associated with BRAFV600E Mutations or Systemic Neurofibromatosis Type 1 (NF1)
This study is currently enrolling.Associated Conditions: Brain CancerResearch Area: Pediatric Research and Clinical TrialsResearch Location: Orlando, FloridaThis study looks at how well a drug called selumetinib works when given to children and young adults with LGG. The study doctors want to see if selumetinib works as well as CV for getting rid of or...
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NCT02954874
A Randomized, Phase III Trial to Evaluate the Efficacy and Safety of MK-3475 (Pembrolizumab) as Adjuvant Therapy for Triple Receptor-Negative Breast Cancer with greater than or equal to 1 cm Residual Invasive Cancer or Positive Lymph Nodes (ypN1mi, ypN1-3) after Neoadjuvant Chemotherapy.
This study is currently enrolling.Associated Conditions: Breast CancerResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThe purpose of this study is to compare the usual approach (no more treatment or additional chemotherapy and radiation therapy after surgery or radiation therapy alone after surgery), with any effects...
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NCT02215265
A Phase III Trial of Risk-Stratified, Reduced Intensity Adjuvant Treatment in Patients Undergoing Transoral Surgery for Human Papillomavarius (HPV)-Positive Oropharyngeal Cancer
This study is currently enrolling.Associated Conditions: Head and Neck CancerResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThis study aims to identify the best way of treating orpharyngeal cancer that are caused by HPV. At the moment, cancers caused by HPV are treated like any other cancer in the Head and Neck and the...
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Impact of Familial Hypercholesterolemia genetic testing on high-risk cardiovascular disease patient outcomes
This study is currently enrolling.Associated Conditions: Genetic Study Familial HypercholesterolemiaResearch Area: Heart, Lung and Vascular ResearchResearch Location: Orlando, FloridaYou are being invited to take part in a research study conducted by the AdventHealth Orlando in collaboration with Helix OpCo, LLC (“Helix”), a genetics company that performs the sequencing of DNA...
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Isolation of Tumor Cells, Cancer Stem Cells and Human Neuronal Stem Cells from Human Brain Tumor Tissue for Analysis of Cancer Stem Cell Markers’ Expression in Cellular Differentiation and Self-renewal for Studying the Effectiveness of Cancer Therapy with Subsequent Identification of Exosomal Biomarkers for Early Diagnostic Purposes
This study is currently enrolling.Associated Conditions: Brain Diseases/CAResearch Area: Neuroscience ResearchResearch Location: Orlando, FloridaThe purpose of this clinical trial is to collect and study brain tumor samples to help understand why the tumor grows back and to seek new ways to treat it.