Search our team at AdventHealth Research Institute
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North American Pediatric Renal Trials Collaborative Studies (NAPRTCS)
This study is currently enrolling.Associated Conditions: TransplantResearch Area: Pediatrics ResearchResearch Location: Orlando, FloridaNAPRTCS is a research effort that was organized in 1987 by a group of physicians and surgeons committed to the success of pediatric renal transplant.
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NCT05602194
A Randomized Trial of Levocarnitine Prophylaxis to Prevent Asparaginase-Associated Hepatotoxicity in Adolescents and Young Adults Receiving Acute Lymphoblastic Leukemia Therapy
This study is not currently enrolling.Associated Conditions: LeukemiaResearch Area: Pediatrics ResearchResearch Location: Orlando, FloridaThe overall goal of this study is to determine whether adding levocarnitine to standard of care ALL treatment will reduce the chances of developing severe liver damage from asparaginase chemotherapy.
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NCT05457556
A Feasibility and Randomized Phase 2/3 Study of the VEFGR2/MET Inhibitor Cabozantinib in Combination with Cytotoxic Chemotherapy for Newly Diagnosed Osteosarcoma
This study is not currently enrolling.Associated Conditions: Bone CancerResearch Area: Pediatrics ResearchThis study looks at how well cabozantinib in combination with MAP work when given to children and young adults with newly diagnosed OST disease. Cabozantinib is experimental because it has not been...
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Donor Breast Milk and Serum Ferritin Levels in Very Preterm Infants: A Prospective, Observational Study
This study is not currently enrolling.Associated Conditions: NeonatalResearch Area: Pediatrics ResearchResearch Location: Orlando, FloridaThe purpose of the study is to compare the iron levels in very preterm infants receiving donor breast milk (DBM) to very preterm infants receiving maternal breast milks (MBM).
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Conservative Fluid Management in the First Week of Life Reduces the Risk of Prolonged Hemodynamically Significant Patent Ductus Arteriosus in Extremely Preterm Infants
This study is not currently enrolling.Research Area: Pediatrics ResearchResearch Location: Orlando, FloridaTo retrospectively collect and analyze the data to show that a change in practice at the Advent Health Orlando Neonatal Intensive Care Unit (NICU), implementing conservative fluid intake during the...
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NCT04185363
An Open-label Extension Study to Evaluate the Long-term Safety and Efficacy of Maralixibat in the Treatment of Subjects with Progressive Familial Intrahepatic Cholestasis (PFIC)
This study is not currently enrolling.Associated Conditions: Wilsons DiseaseResearch Area: Pediatrics ResearchResearch Location: Orlando, FloridaThe primary objective of the study is to evaluate the long-term safety and tolerability of maralixibat. Secondary objectives: To evaluate the long-term efficacy of maralixibat, including the...
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Mother Providing Recorded Voice to Her Preterm Infant in Incubator Improves Her Own Grief and Emotional Status
This study is not currently enrolling.Associated Conditions: NeonatalResearch Area: Pediatrics ResearchResearch Location: Orlando, FloridaStudies have shown that infants prefer the sound of their mother's voice above all others. After 2 weeks (or 14 days) of life, we would like to begin playing a recording to babies of their mother's...
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NCT04538261
Elevation of the Fetal Buttocks Prior to External Cephalic Version
This study is not currently enrolling.Associated Conditions: Neonatal, Care DeliveryResearch Area: Pediatrics ResearchIn this study, we will analyze the available NICU data to determine the predictive value of a Bronchopulmonary Dysplasia (BPD) scoring system. Later, we will determine a threshold score at which an...
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NCT04166409
A Phase 3 Randomized Non-Inferiority Study of Carboplatin and Vincristine versus Selumetinib (NSC# 748727, IND# 77782) in Newly Diagnosed or Previously Untreated Low-Grade Glioma (LGG) not associated with BRAFV600E Mutations or Systemic Neurofibromatosis Type 1 (NF1)
This study is not currently enrolling.Associated Conditions: Brain CancerResearch Area: Pediatrics ResearchResearch Location: Orlando, FloridaThis study looks at how well a drug called selumetinib works when given to children and young adults with LGG. The study doctors want to see if selumetinib works as well as CV for getting rid of or...
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NCT04285658
Pediatric KIDney Stone (PKIDS) Care Improvement Network
This study is not currently enrolling.Associated Conditions: SurgeryResearch Area: Pediatrics ResearchThe purpose of this study is to improve the ability of pediatric patients and their caregivers to select surgical treatment options for kidney stones. The study also aims to help urologists use...
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NCT03871257
A Phase 3 Randomized Study of Selumetinib (IND# 77782) versus Carboplatin/Vincristine in Newly Diagnosed or Previously Untreated Neurofibromatosis Type 1 (NF1) Associated Low-Grade Glioma (LGG)
This study is not currently enrolling.Associated Conditions: Brain CancerResearch Area: Pediatrics ResearchResearch Location: Orlando, FloridaThe overall goals of this study are to see if selumetinib works just as well as the standard treatment of carboplatin/vincristine (CV) for subjects with NF1-associated LGG, and to see if selumetinib...
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NCT02723994
A Phase 2 Study of the JAK1/JAK2 Inhibitor Ruxolitinib with Chemotherapy in Children with De Novo High-Risk CRLF2-Rearranged and/or JAK Pathway-Mutant Acute Lymphoblastic Leukemia
This study is not currently enrolling.Associated Conditions: LeukemiaResearch Area: Pediatrics ResearchThe overall goal of this study are to: Part 1 - Find the best dose of ruxolitinib to use with standard chemotherapy in children, adolescents, and young adults with HR B-ALL; Part 2 - Find out if the...