Photo of Lauren M. Sparks, PhD

Lauren M. Sparks, PhD

Associate Investigator at the Translational Research Institute for Metabolism and Diabetes.

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Expertise of Lauren M. Sparks, PhD

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Biography

Dr. Lauren M. Sparks is an Investigator at the Translational Research Institute. Dr. Sparks pursues investigations on the topics of exercise response variation. Dr. Sparks is interested in understanding why some individuals do not respond favorably to exercise as a means of improving their metabolism and related co-morbidities. She aims to advance the field of exercise and type 2 diabetes and potentially shift the paradigm, allowing interventions to be targeted to those individuals most likely to benefit as well as identify novel approaches to treat those who do not. Dr. Sparks investigates the communication between muscle and fat tissue and how some individuals who are obese, but metabolically healthy, differ from those individuals who are obese and metabolically unhealthy. Prior to joining the TRI, Dr. Sparks was a postdoctoral scientist at Maastricht University in the Netherlands from 2009-2012. She focused on exercise and mitochondrial function in muscle and brown adipose tissue. From 2006-2009, Dr. Sparks was a postdoctoral fellow at Pennington Biomedical Research Center in Baton Rouge, Louisiana with a focus on exercise and substrate metabolism in type 2 diabetes. Dr. Lauren Sparks was born in Patterson, Louisiana. She earned a B.S. in Zoology and a B.A. in Spanish in 2002 and continued on to earn her PhD in Molecular Biology in 2006 from Louisiana State University.

Education

Louisiana State University, Baton Rouge, LA

Publications of Lauren M. Sparks, PhD
  • Skeletal Muscle Composition, Power, and Mitochondrial Energetics in Older Men and Women With Knee Osteoarthritis
    , ARTHRITIS & RHEUMATOLOGY

  • Aging human abdominal subcutaneous white adipose tissue at single cell resolution
    , AGING CELL

  • Leveraging real-world data to predict cancer cachexia stage, quality of life, and survival in a racially and ethnically diverse multi-institutional cohort of treatment-naïve patients with pancreatic ductal adenocarcinoma
    , FRONTIERS IN ONCOLOGY

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  • Muscle Mitochondrial Bioenergetic Capacities Are Associated With Multimorbidity Burden in Older Adults: The Study of Muscle, Mobility and Aging
    , JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

  • The mitochondrial multi-omic response to exercise training across rat tissues
    , CELL METABOLISM

  • Associations between regional adipose tissue distribution and skeletal muscle bioenergetics in older men and women
    , OBESITY

  • Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue
    , NATURE METABOLISM

  • Myokine Secretion following an Aerobic Exercise Intervention in Individuals with Type 2 Diabetes with or without Exercise Resistance
    , INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

  • Isolation of Nuclei from Human Intermuscular Adipose Tissue and Downstream Single-Nuclei RNA Sequencing
    , JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

  • Distinct subpopulations of human subcutaneous adipose tissue precursor cells revealed by single-cell RNA sequencing
    , AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Associated Clinical Trials for Lauren M. Sparks, PhD