Search our team at AdventHealth Research Institute
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NCT05891171
A Phase 1, First-in-Human, Open-Label Study to Evaluate the Safety, Tolerability, PK, and Preliminary Anti-tumor Activity of the Novel Orally Available CDK2 Inhibitor NKT3447 in Adults With Advanced/Metastatic Solid Tumors
This study is currently enrolling.Research Area: Clinical Cancer ResearchObjectives: Primary: Dose Escalation: To identify the recommended doses for expansion (RDEs) of NKT3447 in adult subjects with advanced/metastatic solid tumors Dose Expansion: To evaluate the...
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NCT03671889
Assessment of Safety and Efficacy of Exablate Blood-Brain Barrier Disruption for the Treatment of Patients with Probable Alzheimer’s Disease
This study is currently enrolling.Research Area: Clinical Neuroscience ResearchResearch Location: Celebration, FloridaThe result of this study will help us determine whether blood-brain barrier disruption (BBBD) with Exablate is a safe procedure in the brains of patients with Alzheimer’s Disease. The purpose of this...
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POSEIDON – Prevalence of systemic inflammation in patients with atherosclerotic cardiovascular disease and heart failure
This study is currently enrolling.Research Area: Heart, Lung and Vascular ResearchResearch Location: Tampa, FloridaWe are doing this study to collect information about the number of people with cardiovascular disease who have high levels of inflammation throughout the body. Cardiovascular disease is a general name...
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NCT05919511
MA-GVHD-401: A Prospective, Observational Cohort Study of Participants at Risk for Chronic Graft-Versus-Host Disease in the United States (THRIVE)
This study is currently enrolling.Research Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaDescribe the clinical course and burden of cGVHD after alloSCT. Describe personal and healthcare resource utilization associated with the management of
cGVHD. Describe practice patterns and therapy... -
NCT06040099
D933GC00002: A Phase II Single-Arm Study of Durvalumab and Bevacizumab Following Transarterial Radioembolization Using Yttrium-90 Glass Microspheres (TheraSphere™) in Unresectable Hepatocellular Carcinoma
This study is currently enrolling.Research Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaAstraZeneca is doing this study to learn more about durvalumab and bevacizumab given together after the TARE Y90 procedure in participants with HCC, and also to better understand HCC and associated...
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FABULINUS: A 52-week randomized, double-blind, placebo controlled, multi-center Phase 2b study with a 52-week blinded extension assessing safety and efficacy of frexalimab, a CD40L-antagonist monoclonal antibody, for preservation of pancreatic beta-cell function in adults and adolescents with newly diagnosed type 1 diabetes on insulin therapy.
This study is currently enrolling.Research Area: Translational Research for Metabolism and DiabetesResearch Location: Orlando, FloridaStudy Purpose: The study is aimed to evaluate an investigational drug, frexalimab, for preservation of pancreatic beta cell function in adults and adolescents that have been newly diagnosed with Type...
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NCT06082037
A randomized, double-blind, placebo-controlled, parallel group, Phase 3 study, followed by an open-label extension to evaluate the efficacy of oral belumosudil in adult participants with chronic ling allograft dysfunction (CLAD) following bilateral lung transplantation.
This study is currently enrolling.Research Area: Transplant ResearchThis study will be enrolling subjects who have Stage 1 or 2 chronic lung allograft dysfunction (CLAD) or “chronic lung rejection” after bilateral lung transplantation. This study is to evaluate an...
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NCT05128825
A Phase 2 Open-Label, Multicenter Study To Evaluate Efficacy And Safety Of Zn-C3 In Subjects With High-Grade Serous Ovarian, Fallopian Tube, Or Primary Peritoneal Cancer
This study is currently enrolling.Research Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThe purpose of this Study includes the following: To test the safety of the Study drug and how you will feel while taking the Study drug. To find out what effects, good and/or bad, it has on you and...
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NCT06064877
AV-299-23-301: A Phase 3 Study of Ficlatuzumab in Combination with Cetuximab in Subjects with Recurrent or Metastatic (R/M) HPV-Negative Head and Neck Squamous Cell Carcinoma
This study is currently enrolling.Associated Conditions: ThoracicResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThe main purpose of this study is to investigate the safety, effectiveness, and tolerability (whether side effects can be handled by a participant) of ficlatuzumab at two different doses when given...
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NCT06143891
A randomized, double-blind, multicenter, Phase 3 study to evaluate efficacy and safety of belumosudil in combination with corticosteroids versus placebo in combination with corticosteroids in participants at least 12 years of age with newly diagnosed chronic graft versus host disease (cGVHD)) (ROCKnrol-1)
This study is currently enrolling.Research Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaDemonstrate the superiority of belumosudil in combination with prednisone vs placebo in combination with prednisone in event free survival.
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NCT06305767
A Phase 2, Randomized, Double-blind Study of Adjuvant V940 (mRNA-4157) + Pembrolizumab (MK-3475) vs. Placebo + Pembrolizumab for High-Risk Muscle-Invasive Urothelial Carcinoma (MIUC) Post-Radical Resection
This study is currently enrolling.Associated Conditions: Urothelial CancerResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaTo compare V940 plus pembrolizumab to
placebo plus pembrolizumab with respect to DFS. Hypothesis (H1): V940 plus pembrolizumab is superior to placebo plus pembrolizumab with respect to DFS as assessed... -
NCT03142152
Assessment of the Carillon Mitral Contour System® in Treating Heart Failure with Functional Mitral Regurgitation
This study is currently enrolling.Research Area: Transplant ResearchResearch Location: Orlando, FloridaThe purpose of this clinical study is to evaluate the safety and effectiveness of the Carillon Mitral Contour System in people who have mitral regurgitation resulting from heart failure.