Search our team at AdventHealth Research Institute
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NCT05675410
A Randomized Phase 3 Interim Response Adapted Trial Comparing Standard Therapy with Immuno-oncology Therapy for Children and Adults with Newly Diagnosed Stage I and II Classic Hodgkin Lymphoma
This study is currently enrolling.Associated Conditions: Pediatric CancerResearch Area: Pediatric Research and Clinical TrialsResearch Location: Orlando, FloridaThe overall goal of this study is to compare the effects, good and/or bad, of brentuximab vedotin and nivolumab (Bv-NIVO) against standard therapy for people with HL to find out which is better.
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NCT06172296
A Phase 3 Study of Dinutuximab Added to Intensive Multimodal Therapy for Children with Newly Diagnosed High-Risk Neuroblastoma
This study is currently enrolling.Associated Conditions: NeuroblastomaResearch Area: Pediatric Research and Clinical TrialsResearch Location: Orlando, FloridaThe overall goals of this study are to
Compare the outcomes of dinutuximab given early with Induction therapy to the effects of standard Induction therapy with the addition of dinutuximab later in... -
Efficacy of the AAP discharge recommendations to decrease emergency room visit within 14 days after discharge in well late preterm newborns
This study is currently enrolling.Associated Conditions: NeonatalResearch Area: Pediatric Research and Clinical TrialsResearch Location: Celebration, Florida -
NCT05602194
A Randomized Trial of Levocarnitine Prophylaxis to Prevent Asparaginase-Associated Hepatotoxicity in Adolescents and Young Adults Receiving Acute Lymphoblastic Leukemia Therapy
This study is currently enrolling.Associated Conditions: LeukemiaResearch Area: Pediatric Research and Clinical TrialsResearch Location: Orlando, FloridaThe overall goal of this study is to determine whether adding levocarnitine to standard of care ALL treatment will reduce the chances of developing severe liver damage from asparaginase chemotherapy.
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NCT05778188
A Phase 2, Two-Stage, Randomized, Double-Blind, Placebo-Controlled, Multiple-Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of RLS-0071 in Newborns with Moderate or Severe Hypoxic Ischemic Encephalopathy Undergoing Therapeutic Hypothermia with Long-Term Follow-Up (STAR)
This study is currently enrolling.Research Area: Pediatric Research and Clinical TrialsResearch Location: Orlando, FloridaThis study is being conducted to learn whether the investigational medication, called RLS-0071, may help babies, such as your own, who are affected by hypoxic-ischemic encephalopathy (HIE). HIE is a...
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NCT02582697
Phase 3 Accelerated BEP Trial: A randomized phase 3 trial of accelerated versus standard BEP chemotherapy for patients with intermediate and poor-risk metastatic germ cell tumors.
This study is currently enrolling.Research Area: Pediatric Research and Clinical TrialsResearch Location: Orlando, Florida -
NCT04321031
STARZL NETWORK FOR EXCELLENCE IN PEDIATRIC TRANSPLANTATION (snept) to improve the health of pediatric LIVER TRANSPLANT PATIENTS
This study is currently enrolling.Associated Conditions: Liver DiseaseResearch Area: Pediatric Research and Clinical TrialsResearch Location: Orlando, FloridaPediatric liver transplantation has become the standard of care for many children with liver diseases. However, different institutions often treat and manage children with liver transplant in...
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NCT04166409
A Phase 3 Randomized Non-Inferiority Study of Carboplatin and Vincristine versus Selumetinib (NSC# 748727, IND# 77782) in Newly Diagnosed or Previously Untreated Low-Grade Glioma (LGG) not associated with BRAFV600E Mutations or Systemic Neurofibromatosis Type 1 (NF1)
This study is currently enrolling.Associated Conditions: Brain CancerResearch Area: Pediatric Research and Clinical TrialsResearch Location: Orlando, FloridaThis study looks at how well a drug called selumetinib works when given to children and young adults with LGG. The study doctors want to see if selumetinib works as well as CV for getting rid of or...
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NCT03871257
A Phase 3 Randomized Study of Selumetinib (IND# 77782) versus Carboplatin/Vincristine in Newly Diagnosed or Previously Untreated Neurofibromatosis Type 1 (NF1) Associated Low-Grade Glioma (LGG)
This study is currently enrolling.Associated Conditions: Brain CancerResearch Area: Pediatric Research and Clinical TrialsThe overall goals of this study are to see if selumetinib works just as well as the standard treatment of carboplatin/vincristine (CV) for subjects with NF1-associated LGG, and to see if selumetinib...
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NCT03067181
A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients with Germ Cell Tumors
This study is currently enrolling.Associated Conditions: Brain CancerResearch Area: Pediatric Research and Clinical TrialsResearch Location: Orlando, FloridaLow Risk Subjects (Age <50 Years): The overall goal is to see if monitoring subjects with low risk germ cell tumors after their tumor is removed is as effective as following surgery with chemotherapy...
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NCT03962543
A Phase 2b Trial of the MEK 1/2 Inhibitor (MEKi) PD-0325901 in Adult and Pediatric Patients with Neurofibromatosis Type 1 (NF1)-Associated Inoperable Plexiform Neurofibromas (PNs) that are Progressing or Causing Significant Morbidity
This study is currently enrolling.Associated Conditions: NeurofibromatosisResearch Area: Pediatric Research and Clinical TrialsResearch Location: Orlando, FloridaThis research is conducted to study an investigational drug referred to as PD-0325901 (also known as mirdametinib) that has not been approved by the US Food and Drug Administration (FDA) or any other...
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NCT03334292
Natural History of Wilson Disease: Registry for Patients with Wilson Disease
This study is currently enrolling.Associated Conditions: Wilson’s DiseaseResearch Area: Pediatric Research and Clinical TrialsResearch Location: Orlando, FloridaYou are invited to donate your blood, urine, research data, and related information to be stored (banked) in a research specimen/data database or bank where it can be used for future research projects...