All Clinical Trials
Search our team at AdventHealth Research Institute
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Quantitative and Qualitative in Vitro Evaluation of Emerging Bioengineered Scaffolds for Rotator Cuff Repair
This study is currently enrolling.Research Area: Orthopedic ResearchThe purpose of the study is to investigate the effect of each scaffold on tendon cell attachment and proliferation in vitro in a bioreactor.
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Predicting Non-Union and Optimizing Fracture Fixation by Studying Osteon Properties at the Non-Union Using Micro-CT and Micro Finite Element Analysis
This study is currently enrolling.Research Area: Orthopedic ResearchThe purpose of the study is to identify the differences between individual osteon geometrical properties (size, distribution, density) and microscale properties of non-union and healthy bones...
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NCT05677490
A022102, RANDOMIZED PHASE III TRIAL OF MFOLFIRINOX +/- NIVOLUMAB VS. FOLFOX +/- NIVOLUMAB FOR FIRST-LINE TREATMENT OF METASTATIC HER2-NEGATIVE GASTROESOPHAGEAL ADENOCARCINOMA
This study is currently enrolling.Research Area: Rocky Mountain Cancer ResearchThis phase III trial compares the effect of modified fluorouracil, leucovorin calcium, oxaliplatin, and irinotecan (mFOLFIRINOX) to modified fluorouracil, leucovorin calcium, and oxaliplatin (mFOLFOX)...
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NCT04071457
S1803, Phase III Study of Daratumumab/rHuPH20 (NSC-810307) + Lenalidomide or Lenalidomide as Post-Autologous Stem Cell Transplant Maintenance Therapy in Patients with Multiple Myeloma (MM) Using Minimal Residual Disease to Direct Therapy Duration (DRAMMATIC Study)
This study is currently enrolling.Research Area: Rocky Mountain Cancer ResearchPatients are enrolled to screening (Reg Step 1) prior to or after ASCT but prior to Reg Step 2. Patients are followed until they will begin Maintenance and then registered to Reg Step 2 (first...
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NCT03723928
S1703, Randomized Non-Inferiority Trial Comparing Overall Survival of Patients Monitored with Serum Tumor Marker Directed Disease Monitoring (STMDDM) versus Usual Care in Patients with Metastatic Hormone Receptor Positive HER-2 Negative Breast Cancer
This study is currently enrolling.Research Area: Rocky Mountain Cancer ResearchThis randomized research trial studies how well serum tumor marker directed disease monitoring works in monitoring patients with hormone receptor positive Her2 negative breast cancer that has spread...
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NCT05929768
S2212, SHORTER ANTHRACYCLINE-FREE CHEMO IMMUNOTHERAPY ADAPTED TO PATHOLOGICAL RESPONSE IN EARLY TRIPLE NEGATIVE BREAST CANCER (SCARLET), A RANDOMIZED PHASE III STUDY
This study is currently enrolling.Research Area: Rocky Mountain Cancer ResearchThis is a randomized Phase III trial comparing a standard neoadjuvant chemotherapy regimen to an experimental neoadjuvant chemotherapy regimen that omits AC therapy. Both arms receive pembrolizumab...
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NCT05058651
S2012, Randomized Phase II/III Trial of First Line Platinum/Etoposide with or without Atezolizumab (NSC #783608) in Patients with Advanced or Metastatic Poorly Differentiated Extrapulmonary Neuroendocrine Carcinomas (NEC)
This study is currently enrolling.Research Area: Rocky Mountain Cancer ResearchThis phase II/III trial compares the effect of immunotherapy with atezolizumab in combination with standard chemotherapy with a platinum drug (cisplatin or carboplatin) and etoposide versus standard...
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NCT04248452
EA2183, A Phase III Study of Consolidative Radiotherapy in Patients with Oligometastatic HER2 Negative Esophageal and Gastric Adenocarcinoma (EGA)
This study is currently enrolling.Research Area: Rocky Mountain Cancer ResearchThis phase III trial studies how well the addition of radiotherapy to the usual treatment (chemotherapy) works compared to the usual treatment alone in treating patients with esophageal and gastric...
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NCT04724018
DF/HCC 20-614 Combinatons of Sacituzumab govitecan plus enfortumab vedotin and pembrolizumab for metastatic urothelial carcinoma: the Double Antibody Drug conjugate (DAD) and Double Antibody Drug Conjugate with Immunotherapy (DAD-IO) Phase I/II trial
This study is not currently enrolling.Associated Conditions: Urothelial CancerResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThis research is being done to study the safety and efficacy of two drug combinations. The first combination is Sacituzumab govitecan and enfortumab vedotin, and the second is Sacituzumab govitecan in...
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NCT05666960
RISE: A single and repeat dosing study of the safety, drug exposure, and clinical activity of R-3750 in patients with mild to moderate ulcerative colitis
This study is not currently enrolling.Research Area: Digestive Health and SurgeryResearch Location: Orlando, FloridaThe purpose of this study is to determine if R-3750 DP is safe and to determine how much R-3750 DP (what dosage) to give to people with UC.
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NCT06819007
A Phase 3, Open-label, Multicenter, Randomized Trial of Trastuzumab Deruxtecan with Bevacizumab Versus Bevacizumab Monotherapy as First-line Maintenance Therapy in HER2-Expressing Ovarian Cancer” GOG 3112/ DSI-T-DXd ENHERTU (DO-01); DESTINY-Ovarian01 (DO-01)] DS8201-772
This study is not currently enrolling.Associated Conditions: Ovarian, Fallopian, or Primary Peritoneum CancerResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThis study consists of two parts: Part 1 (safety run-in) and Part 2 (randomized part [like the flip of a coin]). The purpose of Part 1 is to learn more about the safety and tolerability of the...
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NCT05929235
A Phase 1, First-in-Human, Dose-Escalation and Expansion Study of FX-909 in Patients With Advanced Solid Malignancies, Including Advanced Urothelial Carcinoma
This study is not currently enrolling.Associated Conditions: Multiple Tumor TypesResearch Area: Clinical Cancer ResearchResearch Location: Celebration, Florida