Search our team at AdventHealth Research Institute
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NCT04393285
A Phase II Study of Abemaciclib in Combination with Letrozole in Advanced, Recurrent or Metastatic Endometrioid Endometrial Cancer
This study is currently enrolling.Associated Conditions: Endometrial CancerResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThe purpose of this study is to find out if the combination of the drugs abemaciclib and letrozole is better or worse than usual approach for your type of cancer. The usual approach is defined as care...
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NCT02954874
A Randomized, Phase III Trial to Evaluate the Efficacy and Safety of MK-3475 (Pembrolizumab) as Adjuvant Therapy for Triple Receptor-Negative Breast Cancer with greater than or equal to 1 cm Residual Invasive Cancer or Positive Lymph Nodes (ypN1mi, ypN1-3) after Neoadjuvant Chemotherapy.
This study is currently enrolling.Associated Conditions: Breast CancerResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThe purpose of this study is to compare the usual approach (no more treatment or additional chemotherapy and radiation therapy after surgery or radiation therapy alone after surgery), with any effects...
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NCT02215265
A Phase III Trial of Risk-Stratified, Reduced Intensity Adjuvant Treatment in Patients Undergoing Transoral Surgery for Human Papillomavarius (HPV)-Positive Oropharyngeal Cancer
This study is currently enrolling.Associated Conditions: Head and Neck CancerResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThis study aims to identify the best way of treating orpharyngeal cancer that are caused by HPV. At the moment, cancers caused by HPV are treated like any other cancer in the Head and Neck and the...
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NCT03919071
A Phase 2 Study of Dabrafenib (NSC# 763760) with Trametinib (NSC# 763093) after Local Irradiation in Newly Diagnosed BRAFV600-Mutant High-Grade Glioma (HGG) (IND# 145355)
This study is currently enrolling.Associated Conditions: Brain CancerResearch Area: Clinical Cancer ResearchThe study doctors want to see if using dabrafenib and trametinib after radiation treatment will be better than treatments used in the past in helping to get rid of or shrink HGGs. Dabrafenib works by...
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Impact of Familial Hypercholesterolemia genetic testing on high-risk cardiovascular disease patient outcomes
This study is currently enrolling.Associated Conditions: Genetic Study Familial HypercholesterolemiaResearch Area: Heart, Lung and Vascular ResearchResearch Location: Orlando, FloridaYou are being invited to take part in a research study conducted by the AdventHealth Orlando in collaboration with Helix OpCo, LLC (“Helix”), a genetics company that performs the sequencing of DNA...
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Isolation of Tumor Cells, Cancer Stem Cells and Human Neuronal Stem Cells from Human Brain Tumor Tissue for Analysis of Cancer Stem Cell Markers’ Expression in Cellular Differentiation and Self-renewal for Studying the Effectiveness of Cancer Therapy with Subsequent Identification of Exosomal Biomarkers for Early Diagnostic Purposes
This study is currently enrolling.Associated Conditions: Brain Diseases/CAResearch Area: Clinical Neuroscience ResearchResearch Location: Orlando, FloridaThe purpose of this clinical trial is to collect and study brain tumor samples to help understand why the tumor grows back and to seek new ways to treat it.
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NCT03959085
A Phase 3 Randomized Trial of INotuzumab Ozogamicin (IND#: 133494, NSC#: 772518) for Newly Diagnosed High-Risk B-ALL; Risk-Adapted Post-Induction Therapy for High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and Disseminated B-LLy
This study is currently enrolling.Associated Conditions: LeukemiaResearch Area: Clinical Cancer ResearchDisseminated B-Cell Lymphoblastic Lymphoma (B-LLy): The overall goal of this study is to determine the outcomes of subjects with disseminated B-LLy receiving High Risk B-cell Acute Lymphoblastic...
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NCT02981628
A Phase 2 Study of INotuzumab Ozogamicin (NSC# 772518, IND #133494) in Children and Young Adults with Relapsed or Refractory CD22+ B-Acute Lymphoblastic Leukemia (B-ALL)
This study is currently enrolling.Associated Conditions: LeukemiaResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThe overall goal of this study is to find out what effect, good and/or bad, the drug inotuzumab ozogamicin has on children and young adults with relapsed or refractory B-ALL.
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NCT04071327
PHAR - Pulmonary Hypertension Association Registry
This study is currently enrolling.Associated Conditions: Pulmonary HypertensionResearch Area: Heart, Lung and Vascular ResearchResearch Location: Orlando, FloridaWe are asking you to be included in the Pulmonary Hypertension Association (PHA) Registry (PHAR). This is a national project about people who have pulmonary hypertension (PH). We are asking you to...
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NCT03126916
A Phase 3 Study of 131I-Metaiodobenzylguanidine (131I-MIBG) or Crizotinib Added to Intensive Therapy for Children with Newly Diagnosed High-Risk Neuroblastoma
This study is currently enrolling.Associated Conditions: Brain CancerResearch Area: Clinical Cancer ResearchThe overall goals of this study are to: Compare the effects, good and/or bad, of the experimental drug 131I-MIBG added to current COG recommended therapy to the effects of current COG recommended...
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NCT03962543
A Phase 2b Trial of the MEK 1/2 Inhibitor (MEKi) PD-0325901 in Adult and Pediatric Patients with Neurofibromatosis Type 1 (NF1)-Associated Inoperable Plexiform Neurofibromas (PNs) that are Progressing or Causing Significant Morbidity
This study is currently enrolling.Associated Conditions: NeurofibromatosisResearch Area: Pediatric Research and Clinical TrialsResearch Location: Orlando, FloridaThis research is conducted to study an investigational drug referred to as PD-0325901 (also known as mirdametinib) that has not been approved by the US Food and Drug Administration (FDA) or any other...
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NCT00736749
Umbrella Long-Term Follow-Up Protocol
This study is currently enrolling.Associated Conditions: Companion StudyResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThe overall goal of this study is to keep in contact with participants of COG clinical trials, so that up-to-date information will be available about these participants as they get older. This...