Search our team at AdventHealth Research Institute
-
NCT04625270
A Phase 2 Study of VS-6766 (Dual RAF/MEK Inhibitor) Alone and In Combination with Defactinib (FAK Inhibitor) in Recurrent Low-Grade Serous Ovarian Cancer (LGSOC).
This study is currently enrolling.Associated Conditions: Ovarian, Fallopian, or Primary Peritoneum CancerResearch Area: Cancer ResearchResearch Location: Orlando, FloridaThe main aims of this clinical study are to: (a) Find out if the best course of study treatment is to take either VS-6766 alone (monotherapy) or to take VS-6766 together (in combination) with...
-
NCT04221815
IMPROVE: MedStar Cardiovascular Research Network/IMPact on Revascularization Outcomes of intraVascular ultrasound guided treatment of complex lesions and Economic impact
This study is currently enrolling.Associated Conditions: AtherosclerosisResearch Area: Heart, Lung and Vascular ResearchResearch Location: Orlando, FloridaThe study will assess whether the use of IVUS improves subjects’ clinical outcomes at 1 year following this PCI procedure. These subjects will be compared to subjects who did not undergo such IVUS...
-
NCT04291612
Sentinel Lymph Node Endometrial Cancer Trial: A Prospective Multicenter International Single-Arm Observational Trial (SELECT)
This study is currently enrolling.Associated Conditions: Endometrial CancerResearch Area: Cancer ResearchResearch Location: Orlando, FloridaWe are doing this study to find out how often your type of cancer comes back (recurs) after the standard treatment. We also want to see how often the standard treatment results in a buildup of fluid...
-
Pilot Feasibility Study of the Interplay between the Host Gut Microbiome and Efficacy of Treatment for Epithelial Ovarian Cancer Patients Receiving IMmunotherapy
This study is currently enrolling.Associated Conditions: Ovarian, Fallopian, or Primary Peritoneum CancerResearch Area: Cancer ResearchResearch Location: Orlando, FloridaThis research is being done to see if your gut microbiome (microorganisms that live in the gut) could help as a biomarker of clinical response to immunotherapy.
-
NCT04502316
BAROSTIM THERAPY in Heart Failure with Reduced Ejection Fraction A Post-Market Registry with the BAROSTIM NEO System
This study is currently enrolling.Associated Conditions: Heart FailureResearch Area: Heart, Lung and Vascular ResearchResearch Location: Orlando, FloridaYou are invited to participate in a Registry to track the performance of the BAROSTIM NEO Device. You are being invited because you have been implanted with the Device because of your condition called...
-
NCT04393285
A Phase II Study of Abemaciclib in Combination with Letrozole in Advanced, Recurrent or Metastatic Endometrioid Endometrial Cancer
This study is currently enrolling.Associated Conditions: Endometrial CancerResearch Area: Cancer ResearchResearch Location: Orlando, FloridaThe purpose of this study is to find out if the combination of the drugs abemaciclib and letrozole is better or worse than usual approach for your type of cancer. The usual approach is defined as care...
-
NCT02954874
A Randomized, Phase III Trial to Evaluate the Efficacy and Safety of MK-3475 (Pembrolizumab) as Adjuvant Therapy for Triple Receptor-Negative Breast Cancer with greater than or equal to 1 cm Residual Invasive Cancer or Positive Lymph Nodes (ypN1mi, ypN1-3) after Neoadjuvant Chemotherapy.
This study is currently enrolling.Associated Conditions: Breast CancerResearch Area: Cancer ResearchResearch Location: Orlando, FloridaThe purpose of this study is to compare the usual approach (no more treatment or additional chemotherapy and radiation therapy after surgery or radiation therapy alone after surgery), with any effects...
-
NCT02215265
A Phase III Trial of Risk-Stratified, Reduced Intensity Adjuvant Treatment in Patients Undergoing Transoral Surgery for Human Papillomavarius (HPV)-Positive Oropharyngeal Cancer
This study is currently enrolling.Associated Conditions: Head and Neck CancerResearch Area: Cancer ResearchResearch Location: Orlando, FloridaThis study aims to identify the best way of treating orpharyngeal cancer that are caused by HPV. At the moment, cancers caused by HPV are treated like any other cancer in the Head and Neck and the...
-
NCT03919071
A Phase 2 Study of Dabrafenib (NSC# 763760) with Trametinib (NSC# 763093) after Local Irradiation in Newly Diagnosed BRAFV600-Mutant High-Grade Glioma (HGG) (IND# 145355)
This study is currently enrolling.Associated Conditions: Brain CancerResearch Area: Cancer ResearchThe study doctors want to see if using dabrafenib and trametinib after radiation treatment will be better than treatments used in the past in helping to get rid of or shrink HGGs. Dabrafenib works by...
-
Impact of Familial Hypercholesterolemia genetic testing on high-risk cardiovascular disease patient outcomes
This study is currently enrolling.Associated Conditions: Genetic Study Familial HypercholesterolemiaResearch Area: Heart, Lung and Vascular ResearchResearch Location: Orlando, FloridaYou are being invited to take part in a research study conducted by the AdventHealth Orlando in collaboration with Helix OpCo, LLC (“Helix”), a genetics company that performs the sequencing of DNA...
-
Isolation of Tumor Cells, Cancer Stem Cells and Human Neuronal Stem Cells from Human Brain Tumor Tissue for Analysis of Cancer Stem Cell Markers’ Expression in Cellular Differentiation and Self-renewal for Studying the Effectiveness of Cancer Therapy with Subsequent Identification of Exosomal Biomarkers for Early Diagnostic Purposes
This study is currently enrolling.Associated Conditions: Brain Diseases/CAResearch Area: Neuroscience ResearchResearch Location: Orlando, FloridaThe purpose of this clinical trial is to collect and study brain tumor samples to help understand why the tumor grows back and to seek new ways to treat it.
-
NCT03959085
A Phase 3 Randomized Trial of INotuzumab Ozogamicin (IND#: 133494, NSC#: 772518) for Newly Diagnosed High-Risk B-ALL; Risk-Adapted Post-Induction Therapy for High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and Disseminated B-LLy
This study is currently enrolling.Associated Conditions: LeukemiaResearch Area: Cancer ResearchDisseminated B-Cell Lymphoblastic Lymphoma (B-LLy): The overall goal of this study is to determine the outcomes of subjects with disseminated B-LLy receiving High Risk B-cell Acute Lymphoblastic...