Search our team at AdventHealth Research Institute
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NCT04529772
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Acalabrutinib in Combination with Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R CHOP) in Subjects ≤70 Years with Previously Untreated Non-Germinal Center Diffuse Large B Cell Lymphoma
This study is not currently enrolling.Associated Conditions: LeukemiaResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThis study is being done to understand whether patients with a type of DLBCL known as non-germinal center diffuse large B-cell lymphoma (non-GCB DLBCL) will benefit from the addition of acalabrutinib...
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Donor Breast Milk and Serum Ferritin Levels in Very Preterm Infants: A Prospective, Observational Study
This study is not currently enrolling.Associated Conditions: NeonatalResearch Area: Pediatric Research and Clinical TrialsResearch Location: Orlando, FloridaThe purpose of the study is to compare the iron levels in very preterm infants receiving donor breast milk (DBM) to very preterm infants receiving maternal breast milks (MBM).
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NCT03000439
You are being asked to take part in this research study because you have Systemic Juvenile Idiopathic Arthritis (sJIA) which may cause joint swelling and pain, fever, or other symptoms affecting the whole body (such as rash, swelling of your lymph nodes, a large liver or spleen, or inflammation of the lining around your lungs or heart). The purpose of this research study is to compare the effectiveness of the study drug, tofacitinib, to placebo for treatment of signs and symptoms of sJIA.
This study is not currently enrolling.Associated Conditions: Immunology/RheumatologistResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaYou are being asked to take part in this research study because you have Systemic Juvenile Idiopathic Arthritis (sJIA) which may cause joint swelling and pain, fever, or other symptoms affecting the...
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NCT03683186
ADVANCE EXTENSION - A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects with PAH via an Open-Label Extension
This study is not currently enrolling.Research Area: Heart, Lung and Vascular ResearchIf you have taken part in a research study with ralinepag, the investigational study drug, you may be able to take part in this extension study. This means that all participants will receive the...
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NCT04537377
A Phase I/II, Multicenter, Non-randomized, Open Label, Adaptive Design, 5-year Follow up, Single Dose-escalation Study of VTX-801 in Adult Patients with Wilson’s Disease.
This study is not currently enrolling.Associated Conditions: Wilsons DiseaseResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThis Clinical Trial is being conducted to assess the effects of an experimental drug (study drug) called VTX-801 intended to treat Wilson’s Disease (WD). The purpose of this clinical study is to...
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NCT05264922
Stromal Vascular Fraction (SVF) Cells for Non-operative Treatment of Small Rotator Cuff Tears.
This study is not currently enrolling.Associated Conditions: Tendon InjuryResearch Area: Orthopedic ResearchThe purpose of the study is to compare the relative clinical efficacy of placebo injection with exercise program to SVF cell injection with Exercise program in patients with partial thickness Rotator...
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NCT05064878
A Phase 3, Randomized, Double-blind, Placebo-Controlled, Fixed-Dose, Multicenter Study to Examine the Efficacy and Safety of ZX008 in Subjects with CDKL5 deficiency disorder followed by an Open-Label Extension.
This study is not currently enrolling.Associated Conditions: EpilepsyResearch Area: Clinical Neuroscience ResearchResearch Location: Orlando, FloridaThe purpose of this informed consent form is to collect data about the non-paid caregiver of a subject that is participating in ZX008-2103 study. You, as the non-paid caregiver, are being asked to...
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MODIFY: A Case-Control, Observational, Proof of Mechanism Study to Define Microbiome-Mediated Gut Dysfunction Across the Spectrum of Non-Alcoholic Fatty Liver Disease.
This study is not currently enrolling.Associated Conditions: Liver-NAFL, NASHResearch Area: Translational Research for Metabolism and DiabetesThis study is being done to understand if the bacteria that are in your colon (the gut microbiome) get into the cells of the intestinal wall in people with fatty liver or fibrosis compared to people...
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NCT05046730
SEAM Trial: Sutureless End to End Anastomosis by Magnetic Compression: A Study to Evaluate Safety and Effectiveness of the GI Window’s Self-Forming Magnet (SFM) Anastomosis Device: A Historically Controlled Propensity Matched Study
This study is not currently enrolling.Research Area: Digestive Health and SurgeryYou are being asked to participate in this research study because you will be undergoing an ileostomy reversal surgery (also referred to as “ileostomy closure”). A reversal of ileostomy is an...
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NCT04137900
A First-in-Human, Multicenter, Open-Label, Phase 1 Dose-Escalation and Cohort Expansion Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TAB004 as Monotherapy and in Combination with Toripalimab in Subjects with Advanced Solid Malignancies including Lymphoma
This study is not currently enrolling.Associated Conditions: LymphomaResearch Area: Clinical Cancer ResearchThe purpose of this study is to determine the side effects of TAB004 (investigational drug) when given alone or in combination with toripalimab (another investigational drug), to determine a...
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NCT05258942
MyLeukoMAP Genomic Survival Prediction Assay
This study is not currently enrolling.Associated Conditions: Heart FailureResearch Area: Transplant ResearchHeart failure (HF) can cause other organs to shut down. This process appears to involve the white blood cells of the immune system. Our data show that abnormal gene activation or suppression of white...
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NCT03517332
Association of ctDNA and circulating tumor cells after neoadjuvant chemotherapy with disease recurrence in patients with advanced stage epithelial ovarian cancer, fallopian tube cancer, or primary peritoneal cancer.
This study is not currently enrolling.Associated Conditions: Ovarian, Fallopian, or Primary Peritoneum CancerResearch Area: Clinical Cancer ResearchTo compare the levels of ctDNA and CTCs using the SIGNATERA™ test in the peripheral blood of patients during neoadjuvant chemotherapy and after IDS for advanced stage epithelial ovarian carcinoma...